These results open the path towards generation of more realistically vascularized tissue constructs for a variety of personalized medicine applications.ģD Bioprinting has emerged as one of the most promising approaches to fill this gap due to its precision, reproducibility, and high throughput. Moreover, we reverse-engineered the 2D intestinal image-derived designs into cylindrical objects, and 3D-printed them in a support hydrogel. To address this limitation, here we demonstrated an image analysis-based workflow leading through computer-assisted design from anatomic images of rodent mesentery and colon to the actual printing of such patterns with paste and hydrogel bioinks. In general, the perfusion of bioprinted constructs has remained difficult, and the current solution is to provide them with mostly linear and simply branched channels. However, for their integration into functional units useful for experimentation or implantation, the next challenge is to endow them with a larger-scale, anatomically realistic vasculature. Recent progress in bioprinting has made possible the creation of complex 3D intestinal constructs, including vascularized villi.
0 Comments
Leave a Reply. |